Matrix protein from influenza A virus and its role in cross-protection in mice.
Identifieur interne : 002A38 ( Main/Exploration ); précédent : 002A37; suivant : 002A39Matrix protein from influenza A virus and its role in cross-protection in mice.
Auteurs : R G Webster ; V S HinshawSource :
- Infection and Immunity [ 0019-9567 ] ; 1977.
Abstract
The matrix (M) protein of influenza A virus, one of the two group-specific internal proteins of the virion, was isolated in a pure form, and its immunogenicity was stable to heating at 100 degrees C for 2 min. Mice immunized with isolated M protein in complete Freund adjuvant and subsequently infected with influenza virus cleared virus more rapidly from their lungs than did unimmunized mice. Despite the rapid clearance of virus, the mice developed pneumonia that was at least as severe as in unimmunized mice. Preliminary studies suggest that the rapid clearance of influenza virus from the lungs of mice immunized with M protein may be initiated by a cell-mediated rather than a humoral response. The mechanism by which a cross-reactive internal virion protein can initiate clearance of the different subtypes of influenza is not clear. Perhaps the M protein is exposed on the surface of the virus-infected cell and is responsible for the cross-reactivity at the cytotoxic T-cell level recently detected between influenza A virus subtypes.
Url:
PubMed: 409677
PubMed Central: 421163
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000313
- to stream Pmc, to step Curation: 000313
- to stream Pmc, to step Checkpoint: 000E11
- to stream Ncbi, to step Merge: 001103
- to stream Ncbi, to step Curation: 001103
- to stream Ncbi, to step Checkpoint: 001103
- to stream Main, to step Merge: 002B97
- to stream Main, to step Curation: 002A38
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Matrix protein from influenza A virus and its role in cross-protection in mice.</title><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></author><author><name sortKey="Hinshaw, V S" sort="Hinshaw, V S" uniqKey="Hinshaw V" first="V S" last="Hinshaw">V S Hinshaw</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">409677</idno><idno type="pmc">421163</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC421163</idno><idno type="RBID">PMC:421163</idno><date when="1977">1977</date><idno type="wicri:Area/Pmc/Corpus">000313</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000313</idno><idno type="wicri:Area/Pmc/Curation">000313</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000313</idno><idno type="wicri:Area/Pmc/Checkpoint">000E11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E11</idno><idno type="wicri:Area/Ncbi/Merge">001103</idno><idno type="wicri:Area/Ncbi/Curation">001103</idno><idno type="wicri:Area/Ncbi/Checkpoint">001103</idno><idno type="wicri:doubleKey">0019-9567:1977:Webster R:matrix:protein:from</idno><idno type="wicri:Area/Main/Merge">002B97</idno><idno type="wicri:Area/Main/Curation">002A38</idno><idno type="wicri:Area/Main/Exploration">002A38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Matrix protein from influenza A virus and its role in cross-protection in mice.</title><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></author><author><name sortKey="Hinshaw, V S" sort="Hinshaw, V S" uniqKey="Hinshaw V" first="V S" last="Hinshaw">V S Hinshaw</name></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1977">1977</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The matrix (M) protein of influenza A virus, one of the two group-specific internal proteins of the virion, was isolated in a pure form, and its immunogenicity was stable to heating at 100 degrees C for 2 min. Mice immunized with isolated M protein in complete Freund adjuvant and subsequently infected with influenza virus cleared virus more rapidly from their lungs than did unimmunized mice. Despite the rapid clearance of virus, the mice developed pneumonia that was at least as severe as in unimmunized mice. Preliminary studies suggest that the rapid clearance of influenza virus from the lungs of mice immunized with M protein may be initiated by a cell-mediated rather than a humoral response. The mechanism by which a cross-reactive internal virion protein can initiate clearance of the different subtypes of influenza is not clear. Perhaps the M protein is exposed on the surface of the virus-infected cell and is responsible for the cross-reactivity at the cytotoxic T-cell level recently detected between influenza A virus subtypes.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="iai00213-0088-a" xlink:role="562"></graphic></fig></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Hinshaw, V S" sort="Hinshaw, V S" uniqKey="Hinshaw V" first="V S" last="Hinshaw">V S Hinshaw</name><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R G" last="Webster">R G Webster</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A38 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A38 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:421163
|texte= Matrix protein from influenza A virus and its role in cross-protection in mice.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:409677" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
| This area was generated with Dilib version V0.6.33. |  |